Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis

Wangler, Sebastian; Kamali, Amir; Wapp, Christina; Wuertz-Kozak, Karin; Häckel, Sonja; Fortes, Claudia; Benneker, Lorin M; Haglund, Lisbet; Richards, R Geoff; Alini, Mauro; Peroglio, Marianna; Grad, Sibylle

doi:10.1186/s13287-020-02062-2

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Wangler, S., Kamali, A., Wapp, C., Wuertz-Kozak, K., Häckel, S., Fortes, C., Benneker, L. M., Haglund, L., Richards, R. G., Alini, M., Peroglio, M., & Grad, S. (2021). Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis. Stem Cell Research & Therapy, 12, 11. https://doi.org/10.1186/s13287-020-02062-2

Abstract

Background: Mesenchymal stromal cells (MSCs) have been introduced as promising cell source for regenerative medicine. Besides their multilineage differentiation capacity, MSCs release a wide spectrum of bioactive factors. This secretome holds immunomodulatory and regenerative capacities. In intervertebral disc (IVD) cells, application of MSC secretome has been shown to decrease the apoptosis rate, induce proliferation, and promote production of extracellular matrix (ECM). For clinical translation of secretome-based treatment, characte