Publication: Computational Modeling of Designed Ankyrin Repeat Protein Complexes with Their Targets
Computational Modeling of Designed Ankyrin Repeat Protein Complexes with Their Targets
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Radom, F., Paci, E., & Plückthun, A. (2019). Computational Modeling of Designed Ankyrin Repeat Protein Complexes with Their Targets. Journal of Molecular Biology, 431(15), 2852–2868. https://doi.org/10.1016/j.jmb.2019.05.005
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Recombinant therapeutic proteins are playing an ever-increasing role in the clinic. High-affinity binding candidates can be produced in a high-throughput manner through the process of selection and evolution from large libraries, but the structures of the complexes with target protein can only be determined for a small number of them in a costly, low-throughput manner, typically by x-ray crystallography. Reliable modeling of complexes would greatly help to understand their mode of action and improve them by further engineering, for ex
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- Radom, Filip
- Paci, Emanuele
- Plückthun, Andreas
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Radom, F., Paci, E., & Plückthun, A. (2019). Computational Modeling of Designed Ankyrin Repeat Protein Complexes with Their Targets. Journal of Molecular Biology, 431(15), 2852–2868. https://doi.org/10.1016/j.jmb.2019.05.005