Publication: Biofabricating atherosclerotic plaques: In vitro engineering of a three-dimensional human fibroatheroma model
Biofabricating atherosclerotic plaques: In vitro engineering of a three-dimensional human fibroatheroma model
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Mallone, A., Stenger, C., Von Eckardstein, A., Hoerstrup, S. P., & Weber, B. (2018). Biofabricating atherosclerotic plaques: In vitro engineering of a three-dimensional human fibroatheroma model. Biomaterials, 150, 49–59. https://doi.org/10.1016/j.biomaterials.2017.09.034
Abstract
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Atherosclerotic plaques are cholesterol-induced inflammatory niches accumulating in the vascular sub-endothelial space. Cellular and extracellular composition of human plaques is maneuvered by local inflammation that leads to alterations in the original vascular microenvironment and to the recruitment of an invading fibrous layer (fibroatharoma). In the present study we introduce a bioengineered three-dimensional model of human fibroatheroma (ps-plaque) assembled with a tailored hanging-drop protocol. Using vi-SNE based multidimension
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- Mallone, Anna
- Stenger, Chantal
- Von Eckardstein, Arnold
- Hoerstrup, Simon P
- Weber, Benedikt
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Citations
Mallone, A., Stenger, C., Von Eckardstein, A., Hoerstrup, S. P., & Weber, B. (2018). Biofabricating atherosclerotic plaques: In vitro engineering of a three-dimensional human fibroatheroma model. Biomaterials, 150, 49–59. https://doi.org/10.1016/j.biomaterials.2017.09.034
