Publication: Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.
Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.
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Hasan, S., Stucki, M., Hassa, P. O., Imhof, R., Gehrig, P., Hunziker, P., Hübscher, U., & Hottiger, M. O. (2001). Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300. Molecular Cell, 7(6), 1221–1231. https://doi.org/10.1016/S1097-2765(01)00272-6
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We describe a role for the transcriptional coactivator p300 in DNA metabolism. p300 formed a complex with flap endonuclease-1 (Fen1) and acetylated Fen1 in vitro. Furthermore, Fen1 acetylation was observed in vivo and was enhanced upon UV treatment of human cells. Remarkably, acetylation of the Fen1 C terminus by p300 significantly reduced Fen1's DNA binding and nuclease activity. Proliferating cell nuclear antigen (PCNA) was able to stimulate both acetylated and unacetylated Fen1 activity to the same extent. Our results identify acet
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- Hasan, S
- Stucki, M
- Hassa, P O
- Imhof, R
- Gehrig, P
- Hunziker, P
- Hübscher, U
- Hottiger, M O
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Hasan, S., Stucki, M., Hassa, P. O., Imhof, R., Gehrig, P., Hunziker, P., Hübscher, U., & Hottiger, M. O. (2001). Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300. Molecular Cell, 7(6), 1221–1231. https://doi.org/10.1016/S1097-2765(01)00272-6