Publication: Cardiovascular effects of flavanol-rich chocolate in patients with heart failure
Cardiovascular effects of flavanol-rich chocolate in patients with heart failure
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Flammer, A. J., Sudano, I., Wolfrum, M., Thomas, R., Enseleit, F., Périat, D., Kaiser, P., Hirt, A., Hermann, M., Serafini, M., Lévêques, A., Lüscher, T. F., Ruschitzka, F., Noll, G., & Corti, R. (2012). Cardiovascular effects of flavanol-rich chocolate in patients with heart failure. European Heart Journal, 33(17), 2172–2180. https://doi.org/10.1093/eurheartj/ehr448
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AimsFlavanol-rich chocolate (FRC) is beneficial for vascular and platelet function by increasing nitric oxide bioavailability and decreasing oxidative stress. Congestive heart failure (CHF) is characterized by impaired endothelial and increased platelet reactivity. As statins are ineffective in CHF, alternative therapies are a clinical need. We therefore investigated whether FRC might improve cardiovascular function in patients with CHF.Methods and resultsTwenty patients with CHF were enrolled in a double-blind, randomized placebo-con
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- Flammer, A J
- Sudano, I
- Wolfrum, M
- Thomas, R
- Enseleit, F
- Périat, D
- Kaiser, P
- Hirt, A
- Hermann, M
- Serafini, M
- Lévêques, A
- Lüscher, T F
- Ruschitzka, F
- Noll, G
- Corti, R
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Flammer, A. J., Sudano, I., Wolfrum, M., Thomas, R., Enseleit, F., Périat, D., Kaiser, P., Hirt, A., Hermann, M., Serafini, M., Lévêques, A., Lüscher, T. F., Ruschitzka, F., Noll, G., & Corti, R. (2012). Cardiovascular effects of flavanol-rich chocolate in patients with heart failure. European Heart Journal, 33(17), 2172–2180. https://doi.org/10.1093/eurheartj/ehr448
