Publication: Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4'-derivatives
Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4'-derivatives
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Sonousi, A., Shcherbakov, D., Vasella, A., Böttger, E. C., & Crich, D. (2019). Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4’-derivatives. MedChemComm, 10(6), 946–950. https://doi.org/10.1039/c9md00153k
Abstract
Abstract
Abstract
Halogenation of a suitably protected netilmicin derivative enables preparation of 4'-chloro-, bromo-, and iodo derivatives of netilmicin after deprotection. Suzuki coupling of a protected 4'-bromo derivative with phenylboronic acid or butyltrifluoroborate affords the corresponding 4'-phenyl and 4'-butyl derivatives of netilmicin. Sulfenylation of suitably protected netilmicin derivative with ethanesulfenyl chloride followed by deprotection affords 4'-ethylsulfanylnetilmicin. All netilmicin 4'-derivatives displayed reduced levels of in
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Creators (Authors)
- Sonousi, Amr
- Shcherbakov, Dimitri
- Vasella, Andrea
- Böttger, Erik C
- Crich, David
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Citations
Sonousi, A., Shcherbakov, D., Vasella, A., Böttger, E. C., & Crich, D. (2019). Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4’-derivatives. MedChemComm, 10(6), 946–950. https://doi.org/10.1039/c9md00153k
