Chicago classification version 4.0 © technical review: Update on standard high-resolution manometry protocol for the assessment of esophageal motility

Fox, Mark R; Sweis, Rami; Yadlapati, Rena; Pandolfino, John; Hani, Albis; Defilippi, Claudia; Jan, Tack; Rommel, Nathalie

doi:10.1111/nmo.14120

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Fox, M. R., Sweis, R., Yadlapati, R., Pandolfino, J., Hani, A., Defilippi, C., Jan, T., & Rommel, N. (2021). Chicago classification version 4.0 © technical review: Update on standard high-resolution manometry protocol for the assessment of esophageal motility. Neurogastroenterology and Motility, 33(4), e14120. https://doi.org/10.1111/nmo.14120

Abstract

The Chicago Classification v4.0 (CCv4.0) is the updated classification scheme for esophageal motility disorders using metrics from high-resolution manometry (HRM). A key feature of CCv.4.0 is the more rigorous and expansive protocol that incorporates single wet swallows acquired in different positions (supine, upright) and provocative testing, including multiple rapid swallows and rapid drink challenge. Additionally, solid bolus swallows, solid test meal, and/or pharmacologic provocation can be used to identify clinically relevant mot