Publication: The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer’s disease
The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer’s disease
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Kirabali, T., Rigotti, S., Siccoli, A., Liebsch, F., Shobo, A., Hock, C., Nitsch, R. M., Multhaup, G., & Kulic, L. (2019). The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer’s disease. Acta Neuropathologica Communications, 7, 194. https://doi.org/10.1186/s40478-019-0846-8
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An impairment of amyloid β-peptide (Aβ) clearance is suggested to play a key role in the pathogenesis of sporadic Alzheimer’s disease (AD). Amyloid degradation is mediated by various mechanisms including fragmentation by enzymes like neprilysin, matrix metalloproteinases (MMPs) and a recently identified amyloidolytic activity of β-site amyloid precursor protein cleaving enzyme 1 (BACE1). BACE1 cleavage of Aβ40 and Aβ42 results in the formation of a common Aβ34 intermediate which was found elevated in cerebrospinal fluid levels of pati
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- Kirabali, Tunahan
- Rigotti, Serena
- Siccoli, Alessandro
- Liebsch, Filip
- Shobo, Adeola
- Hock, Christoph
- Nitsch, Roger M
- Multhaup, Gerhard
- Kulic, Luka
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Kirabali, T., Rigotti, S., Siccoli, A., Liebsch, F., Shobo, A., Hock, C., Nitsch, R. M., Multhaup, G., & Kulic, L. (2019). The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer’s disease. Acta Neuropathologica Communications, 7, 194. https://doi.org/10.1186/s40478-019-0846-8
