Publication: High PIRCHE Scores May Allow Risk Stratification of Borderline Rejection in Kidney Transplant Recipients
High PIRCHE Scores May Allow Risk Stratification of Borderline Rejection in Kidney Transplant Recipients
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Lezoeva, E., Nilsson, J., Wüthrich, R., Mueller, T. F., & Schachtner, T. (2022). High PIRCHE Scores May Allow Risk Stratification of Borderline Rejection in Kidney Transplant Recipients. Frontiers in Immunology, 13, 788818. https://doi.org/10.3389/fimmu.2022.788818
Abstract
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BackgroundThe diagnosis of borderline rejection (BLR) ranges from mild inflammation to clinically significant TCMR and is associated with an increased risk of allograft dysfunction. Currently, there is no consensus regarding its treatment due in part to a lack of biomarkers to identify cases with increased risk for immune-mediated injury.MethodsWe identified 60 of 924 kidney transplant recipients (KTRs) with isolated and untreated BLR. We analyzed the impact of predicted indirectly recognizable HLA epitopes (PIRCHE) score on future re
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- Lezoeva, Ekaterina
- Nilsson, Jakob
- Wüthrich, Rudolf
- Mueller, Thomas F
- Schachtner, Thomas
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Lezoeva, E., Nilsson, J., Wüthrich, R., Mueller, T. F., & Schachtner, T. (2022). High PIRCHE Scores May Allow Risk Stratification of Borderline Rejection in Kidney Transplant Recipients. Frontiers in Immunology, 13, 788818. https://doi.org/10.3389/fimmu.2022.788818
