Publication: The X-ray Structures of Six Octameric RNA Duplexes in the Presence of Different Di- and Trivalent Cations
The X-ray Structures of Six Octameric RNA Duplexes in the Presence of Different Di- and Trivalent Cations
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Schaffer, M. F., Peng, G., Spingler, B., Schnabl, J., Wang, M., Olieric, V., & Sigel, R. K. O. (2016). The X-ray Structures of Six Octameric RNA Duplexes in the Presence of Different Di- and Trivalent Cations. International Journal of Molecular Sciences, 17(7), 988. https://doi.org/10.3390/ijms17070988
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Due to the polyanionic nature of RNA, the principles of charge neutralization and electrostatic condensation require that cations help to overcome the repulsive forces in order for RNA to adopt a three-dimensional structure. A precise structural knowledge of RNA-metal ion interactions is crucial to understand the mechanism of metal ions in the catalytic or regulatory activity of RNA. We solved the crystal structure of an octameric RNA duplex in the presence of the di- and trivalent metal ions Ca2+, Mn2+, Co2+, Cu2+, Sr2+, and Tb3+. Th
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- Schaffer, Michelle F
- Peng, Guanya
- Schnabl, Joachim
- Wang, Meitian
- Olieric, Vincent
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Schaffer, M. F., Peng, G., Spingler, B., Schnabl, J., Wang, M., Olieric, V., & Sigel, R. K. O. (2016). The X-ray Structures of Six Octameric RNA Duplexes in the Presence of Different Di- and Trivalent Cations. International Journal of Molecular Sciences, 17(7), 988. https://doi.org/10.3390/ijms17070988
