Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat

Mathes, Clare M; Bohnenkamp, Ryan A; Blonde, Ginger D; Letourneau, Chanel; Corteville, Caroline; Bueter, Marco; Lutz, Thomas A; le Roux, Carel W; Spector, Alan C

doi:10.1016/j.physbeh.2015.02.004

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Mathes, C. M., Bohnenkamp, R. A., Blonde, G. D., Letourneau, C., Corteville, C., Bueter, M., Lutz, T. A., le Roux, C. W., & Spector, A. C. (2015). Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat. Physiology and Behavior, 142, 179–188. https://doi.org/10.1016/j.physbeh.2015.02.004

Abstract

After Roux-en-Y gastric bypass (RYGB) surgery, patients report consuming fewer fatty and dessert-like foods, and rats display blunted sugar and fat preferences. Here we used a progressive ratio (PR) task in our rat model to explicitly test whether RYGB decreases the willingness of rats to work for very small amounts of preferred sugar- and/or fat-containing fluids. In each of two studies, two groups of rats - one maintained on a high-fat diet (HFD) and standard chow (CHOW) and one given CHOW alone - were trained while water-deprived t