Publication: A Nickel(II)-Containing Vitamin B12 Derivative with a Cofactor-F430-type π-System
A Nickel(II)-Containing Vitamin B12 Derivative with a Cofactor-F430-type π-System
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Brenig, C., Prieto, L., Oetterli, R., & Zelder, F. (2018). A Nickel(II)-Containing Vitamin B12 Derivative with a Cofactor-F430-type π-System. Angewandte Chemie Internationale Edition, 57(50), 16308–16312. https://doi.org/10.1002/anie.201810983
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F430 is a unique enzymatic cofactor in the production and oxidation of methane by strictly anaerobic bacteria. The key enzyme methyl coenzyme M reductase (MCR) contains a hydroporphinoid nickel complex with a characteristic absorption maximum at around 430 nm in its active site. Herein, the three‐step semisynthesis of a hybrid NiII‐containing corrinoid that partly resembles F430 in its structural and spectroscopic features from vitamin B12 is presented. A key step of the route is the simultaneous demetalation and ring closure reaction
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- Brenig, Christopher
- Prieto, Lucas
- Oetterli, René
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Brenig, C., Prieto, L., Oetterli, R., & Zelder, F. (2018). A Nickel(II)-Containing Vitamin B12 Derivative with a Cofactor-F430-type π-System. Angewandte Chemie Internationale Edition, 57(50), 16308–16312. https://doi.org/10.1002/anie.201810983
