Publication: Striatal dysfunction during reversal learning in unmedicated schizophrenia patients
Striatal dysfunction during reversal learning in unmedicated schizophrenia patients
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Schlagenhauf, F., Huys, Q. J. M., Deserno, L., Rapp, M. A., Beck, A., Heinze, H.-J., Dolan, R., & Heinz, A. (2013). Striatal dysfunction during reversal learning in unmedicated schizophrenia patients. NeuroImage, 89C, 171–180. https://doi.org/10.1016/j.neuroimage.2013.11.034
Abstract
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Abstract
Subjects with schizophrenia are impaired at reinforcement-driven reversal learning from as early as their first episode. The neurobiological basis of this deficit is unknown. We obtained behavioral and fMRI data in 24 unmedicated, primarily first episode, schizophrenia patients and 24 age-, IQ- and gender-matched healthy controls during a reversal learning task. We supplemented our fMRI analysis, focusing on learning from prediction errors, with detailed computational modeling to probe task solving strategy including an ability to dep
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Creators (Authors)
- Schlagenhauf, Florian
- Huys, Quentin J M
- Deserno, Lorenz
- Rapp, Michael A
- Beck, Anne
- Heinze, Hans-Joachim
- Dolan, Ray
- Heinz, Andreas
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Schlagenhauf, F., Huys, Q. J. M., Deserno, L., Rapp, M. A., Beck, A., Heinze, H.-J., Dolan, R., & Heinz, A. (2013). Striatal dysfunction during reversal learning in unmedicated schizophrenia patients. NeuroImage, 89C, 171–180. https://doi.org/10.1016/j.neuroimage.2013.11.034