Publication: Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells
Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells
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de Andrade Pereira, B., Ackermann, M., Chaudhary, S., Vogel, R., Vogt, B., Dresch, C., & Fraefel, C. (2015). Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells. Gene Therapy, 22(5), 382–390. https://doi.org/10.1038/gt.2015.6
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We have recently shown that targeted expression of myelin oligodendrocyte glycoprotein (MOG) to dendritic cells with self-inactivating-lentivirus vectors induces antigen-specific tolerance in naive antigen-specific CD4+ T cells and protects mice from experimental autoimmune encephalomyelitis (EAE). In the present study, we demonstrate that this approach also induces tolerance of activated antigen-specific CD4+ T cells and completely protects mice from passive EAE induction. Tolerance induction did not correlate with the depletion of t
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- de Andrade Pereira, Bruna
- Ackermann, M
- Chaudhary, S
- Vogel, Rebecca
- Vogt, Bernd
- Dresch, C
- Fraefel, Cornel
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de Andrade Pereira, B., Ackermann, M., Chaudhary, S., Vogel, R., Vogt, B., Dresch, C., & Fraefel, C. (2015). Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells. Gene Therapy, 22(5), 382–390. https://doi.org/10.1038/gt.2015.6