Rapid Detection of PBP2a in Staphylococci from Shortly Incubated Subcultures of Positive Blood Cultures by an Immunochromatographic Assay

Kolesnik-Goldmann, Natalia; Bodendoerfer, Elias; Röthlin, Kim; Herren, Sebastian; Imkamp, Frank; Marchesi, Martina; Mancini, Stefano

doi:10.1128/Spectrum.00462-21

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Kolesnik-Goldmann, N., Bodendoerfer, E., Röthlin, K., Herren, S., Imkamp, F., Marchesi, M., & Mancini, S. (2021). Rapid Detection of PBP2a in Staphylococci from Shortly Incubated Subcultures of Positive Blood Cultures by an Immunochromatographic Assay. Microbiology Spectrum, 9(1), e0046221. https://doi.org/10.1128/Spectrum.00462-21

Abstract

Staphylococcus aureus, as well as coagulase-negative staphylococci (CoNS), can cause a wide range of human infections both in nosocomial and community settings. Βeta-lactams are the antibiotics of choice for the treatment of bloodstream infections (BSI) caused by these microorganisms. Resistance to virtually all β-lactams (also referred to as methicillin resistance) primarily results from the production of an alternative penicillin-binding protein (PBP2a) encoded by the mecA gene. While β-lactams are still used as first-line therapy a