Publication: Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma
Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma
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Bliziotis, N. G., Kluijtmans, L. A. J., Soto, S., Tinnevelt, G. H., Langton, K., Robledo, M., Pamporaki, C., Engelke, U. F. H., Erlic, Z., Engel, J., Deutschbein, T., Nölting, S., Prejbisz, A., Richter, S., Prehn, C., Adamski, J., Januszewicz, A., Reincke, M., Fassnacht, M., … Timmers, H. J. L. M. (2022). Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma. Endocrine, 75(1), 254–265. https://doi.org/10.1007/s12020-021-02858-z
Abstract
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PURPOSE
Pheochromocytomas and Paragangliomas (PPGL) result in chronic catecholamine excess and serious health complications. A recent study obtained a metabolic signature in plasma from PPGL patients; however, its targeted nature may have generated an incomplete picture and a broader approach could provide additional insights. We aimed to characterize the plasma metabolome of PPGL patients before and after surgery, using an untargeted approach, and to broaden the scope of the investigated metabolic impact of these tumors.
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- Bliziotis, Nikolaos G
- Kluijtmans, Leo A J
- Soto, Sebastian
- Tinnevelt, Gerjen H
- Langton, Katharina
- Robledo, Mercedes
- Pamporaki, Christina
- Engelke, Udo F H
- Erlic, Zoran
- Engel, Jasper
- Deutschbein, Timo
- Nölting, Svenja
- Prejbisz, Aleksander
- Richter, Susan
- Prehn, Cornelia
- Adamski, Jerzy
- Januszewicz, Andrzej
- Reincke, Martin
- Fassnacht, Martin
- Eisenhofer, Graeme
- Beuschlein, Felix
- Kroiss, Matthias
- Wevers, Ron A
- Jansen, Jeroen J
- Deinum, Jaap
- Timmers, Henri J L M
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Bliziotis, N. G., Kluijtmans, L. A. J., Soto, S., Tinnevelt, G. H., Langton, K., Robledo, M., Pamporaki, C., Engelke, U. F. H., Erlic, Z., Engel, J., Deutschbein, T., Nölting, S., Prejbisz, A., Richter, S., Prehn, C., Adamski, J., Januszewicz, A., Reincke, M., Fassnacht, M., … Timmers, H. J. L. M. (2022). Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma. Endocrine, 75(1), 254–265. https://doi.org/10.1007/s12020-021-02858-z
