Publication: fac-TcO(3)(tacn)](+): A versatile precursor for the labelling of pharmacophores, amino acids and carbohydrates through a new ligand-centred labelling strategy
fac-TcO(3)(tacn)](+): A versatile precursor for the labelling of pharmacophores, amino acids and carbohydrates through a new ligand-centred labelling strategy
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Braband, H., Tooyama, Y., Fox, T., Simms, R., Forbes, J., Valliant, J. F., & Alberto, R. (2011). fac-TcO(3)(tacn)](+): A versatile precursor for the labelling of pharmacophores, amino acids and carbohydrates through a new ligand-centred labelling strategy. Chemistry, 17(46), 12967–12974. https://doi.org/10.1002/chem.201101275
Abstract
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Herein, we report a protocol for the synthesis of (99m)TcO(3)(tacn)](+) (1](+)) (tacn=1,4,7-triazacyclononane) that is suitable for clinical translation. Bioconjugates containing pharmacophores (TcO(NO(2)-Imi)(tacn)](+); 3](+)), artificial amino acids (TcO(Fmocallyl-His)(tacn)](+); 5](+)), and glucose derivatives (TcO(allyl-tetraacetyl-glucose) (tacn)](+); 7](+)) were synthesized by cycloaddition strategies and fully characterized ((99)Tc and (99m)Tc). These new technetium complexes are stable at neutral pH and demonstrate the potenti
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- Tooyama, Y
- Fox, T
- Simms, R
- Forbes, J
- Valliant, J F
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Braband, H., Tooyama, Y., Fox, T., Simms, R., Forbes, J., Valliant, J. F., & Alberto, R. (2011). fac-TcO(3)(tacn)](+): A versatile precursor for the labelling of pharmacophores, amino acids and carbohydrates through a new ligand-centred labelling strategy. Chemistry, 17(46), 12967–12974. https://doi.org/10.1002/chem.201101275