Publication: Biomphalaria glabrata metallothionein: lacking metal specificity of the protein and missing gene upregulation suggest metal sequestration by exchange instead of through selective binding
Biomphalaria glabrata metallothionein: lacking metal specificity of the protein and missing gene upregulation suggest metal sequestration by exchange instead of through selective binding
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Niederwanger, M., Calatayud, S., Zerbe, O., Atrian, S., Albalat, R., Capdevila, M., Palacios, O., & Dallinger, R. (2017). Biomphalaria glabrata metallothionein: lacking metal specificity of the protein and missing gene upregulation suggest metal sequestration by exchange instead of through selective binding. International Journal of Molecular Sciences, 18, 1457. https://doi.org/10.3390/ijms18071457
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Abstract
The wild-type metallothionein (MT) of the freshwater snail Biomphalaria glabrata and a natural allelic mutant of it in which a lysine residue was replaced by an asparagine residue, were recombinantly expressed and analyzed for their metal-binding features with respect to Cd2+, Zn2+ and Cu+, applying spectroscopic and mass-spectrometric methods. In addition, the upregulation of the Biomphalaria glabrata MT gene was assessed by quantitative real-time detection PCR. The two recombinant proteins revealed to be very similar in most of thei
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- Niederwanger, Michael
- Calatayud, Sara
- Zerbe, Oliver
- Atrian, Silvia
- Albalat, Ricard
- Capdevila, Merce
- Palacios, Oscar
- Dallinger, Reinhard
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Niederwanger, M., Calatayud, S., Zerbe, O., Atrian, S., Albalat, R., Capdevila, M., Palacios, O., & Dallinger, R. (2017). Biomphalaria glabrata metallothionein: lacking metal specificity of the protein and missing gene upregulation suggest metal sequestration by exchange instead of through selective binding. International Journal of Molecular Sciences, 18, 1457. https://doi.org/10.3390/ijms18071457
