Publication: Protein quality control: the who’s who, the where’s and therapeutic escapes
Protein quality control: the who’s who, the where’s and therapeutic escapes
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Roth, J., Yam, G. H.-F., Fan, J., Hirano, K., Gaplovska-Kysela, K., Fourn, V., Guhl, B., Santimaria, R., Torossi, T., Ziak, M., & Zuber, C. (2008). Protein quality control: the who’s who, the where’s and therapeutic escapes. Histochemistry and Cell Biology, 129(2), 163–177. https://doi.org/10.1007/s00418-007-0366-7
Abstract
Abstract
Abstract
In cells the quality of newly synthesized proteins is monitored in regard to proper folding and correct assembly in the early secretory pathway, the cytosol and the nucleoplasm. Proteins recognized as non-native in the ER will be removed and degraded by a process termed ERAD. ERAD of aberrant proteins is accompanied by various changes of cellular organelles and results in protein folding diseases. This review focuses on how the immunocytochemical labeling and electron microscopic analyses have helped to disclose the in situ subcellula
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Creators (Authors)
- Roth, Jürgen
- Yam, Gary Hin-Fai
- Fan, Jingyu
- Hirano, Kiyoko
- Gaplovska-Kysela, Katarina
- Guhl, Bruno
- Santimaria, Roger
- Torossi, Tania
- Ziak, Martin
- Zuber, Christian
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Citations
Roth, J., Yam, G. H.-F., Fan, J., Hirano, K., Gaplovska-Kysela, K., Fourn, V., Guhl, B., Santimaria, R., Torossi, T., Ziak, M., & Zuber, C. (2008). Protein quality control: the who’s who, the where’s and therapeutic escapes. Histochemistry and Cell Biology, 129(2), 163–177. https://doi.org/10.1007/s00418-007-0366-7
