Publication: Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus
Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus
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de Groot, T., Sinke, A. P., Kortenoeven, M. L. A., Alsady, M., Baumgarten, R., Devuyst, O., Loffing, J., Wetzels, J. F., & Deen, P. M. T. (2016). Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus. Journal of the American Society of Nephrology (JASN), 27(7), 2082–2091. https://doi.org/10.1681/ASN.2015070796
Abstract
Abstract
Abstract
To reduce lithium-induced nephrogenic diabetes insipidus (lithium-NDI), patients with bipolar disorder are treated with thiazide and amiloride, which are thought to induce antidiuresis by a compensatory increase in prourine uptake in proximal tubules. However, thiazides induced antidiuresis and alkalinized the urine in lithium-NDI mice lacking the sodium-chloride cotransporter, suggesting that inhibition of carbonic anhydrases (CAs) confers the beneficial thiazide effect. Therefore, we tested the effect of the CA-specific blocker acet
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Creators (Authors)
- de Groot, Theun
- Sinke, Anne P
- Kortenoeven, Marleen L A
- Alsady, Mohammad
- Baumgarten, Ruben
- Devuyst, Olivier
- Loffing, Johannes
- Wetzels, Jack F
- Deen, Peter M T
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Citations
de Groot, T., Sinke, A. P., Kortenoeven, M. L. A., Alsady, M., Baumgarten, R., Devuyst, O., Loffing, J., Wetzels, J. F., & Deen, P. M. T. (2016). Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus. Journal of the American Society of Nephrology (JASN), 27(7), 2082–2091. https://doi.org/10.1681/ASN.2015070796
