Publication: Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness
Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness
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Takizawa, H., Fritsch, K., Kovtonyuk, L. V., Saito, Y., Yakkala, C., Jacobs, K., Ahuja, A. K., Lopes, M., Hausmann, A., Hardt, W.-D., Gomariz, Á., Nombela-Arrieta, C., & Manz, M. G. (2017). Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness. Cell Stem Cell, 21(2), 225-240.e5. https://doi.org/10.1016/j.stem.2017.06.013
Abstract
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Abstract
Bacterial infection leads to consumption of short-lived innate immune effector cells, which then need to be replenished from hematopoietic stem and progenitor cells (HSPCs). HSPCs express pattern recognition receptors, such as Toll-like receptors (TLRs), and ligation of these receptors induces HSPC mobilization, cytokine production, and myeloid differentiation. The underlying mechanisms involved in pathogen signal transduction in HSCs and the resulting biological consequences remain poorly defined. Here, we show that in vivo lipopolys
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- Takizawa, Hitoshi
- Fritsch, Kristin
- Kovtonyuk, Larisa V
- Saito, Yasuyuki
- Yakkala, Chakradhar
- Jacobs, Kurt
- Ahuja, Akshay K
- Lopes, Massimo
- Hausmann, Annika
- Hardt, Wolf-Dietrich
- Gomariz, Álvaro
- Nombela-Arrieta, César
- Manz, Markus G
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Takizawa, H., Fritsch, K., Kovtonyuk, L. V., Saito, Y., Yakkala, C., Jacobs, K., Ahuja, A. K., Lopes, M., Hausmann, A., Hardt, W.-D., Gomariz, Á., Nombela-Arrieta, C., & Manz, M. G. (2017). Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness. Cell Stem Cell, 21(2), 225-240.e5. https://doi.org/10.1016/j.stem.2017.06.013
