Publication: FGF2 overrides key pro-fibrotic features of bone marrow stromal cells isolated from Modic type 1 change patients
FGF2 overrides key pro-fibrotic features of bone marrow stromal cells isolated from Modic type 1 change patients
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Heggli, I., Blache, U., Herger, N., Mengis, T., Jaeger, P. K., Schuepbach, R., Farshad-Amacker, N., Brunner, F., Snedeker, J. G., Farshad, M., Distler, O., & Dudli, S. (2022). FGF2 overrides key pro-fibrotic features of bone marrow stromal cells isolated from Modic type 1 change patients. European Cells and Materials (ECM), 44, 101–114. https://doi.org/10.22203/eCM.v044a07
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Extensive extracellular matrix production and increased cell-matrix adhesion by bone marrow stromal cells (BMSCs) are hallmarks of fibrotic alterations in the vertebral bone marrow known as Modic type 1 changes (MC1). MC1 are associated with non-specific chronic low-back pain. To identify treatment targets for MC1, in vitro studies using patient BMSCs are important to reveal pathological mechanisms. For the culture of BMSCs, fibroblast growth factor 2 (FGF2) is widely used. However, FGF2 has been shown to suppress matrix synthesis in
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- Heggli, Irina
- Blache, Ulrich
- Herger, Nick
- Mengis, Tamara
- Jaeger, Patrick K
- Schuepbach, Regula
- Farshad-Amacker, Nadja
- Brunner, Florian
- Snedeker, Jess G
- Farshad, Mazda
- Distler, Oliver
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Heggli, I., Blache, U., Herger, N., Mengis, T., Jaeger, P. K., Schuepbach, R., Farshad-Amacker, N., Brunner, F., Snedeker, J. G., Farshad, M., Distler, O., & Dudli, S. (2022). FGF2 overrides key pro-fibrotic features of bone marrow stromal cells isolated from Modic type 1 change patients. European Cells and Materials (ECM), 44, 101–114. https://doi.org/10.22203/eCM.v044a07
