Publication: A computational framework for the inference of protein complex remodeling from whole-proteome measurements
A computational framework for the inference of protein complex remodeling from whole-proteome measurements
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Buljan, M., Banaei-Esfahani, A., Blattmann, P., Meier-Abt, F., Shao, W., Vitek, O., Tang, H., & Aebersold, R. (2023). A computational framework for the inference of protein complex remodeling from whole-proteome measurements. Nature Methods, 20, 1523–1529. https://doi.org/10.1038/s41592-023-02011-w
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Protein complexes are responsible for the enactment of most cellular functions. For the protein complex to form and function, its subunits often need to be present at defined quantitative ratios. Typically, global changes in protein complex composition are assessed with experimental approaches that tend to be time consuming. Here, we have developed a computational algorithm for the detection of altered protein complexes based on the systematic assessment of subunit ratios from quantitative proteomic measurements. We applied it to meas
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Buljan, M., Banaei-Esfahani, A., Blattmann, P., Meier-Abt, F., Shao, W., Vitek, O., Tang, H., & Aebersold, R. (2023). A computational framework for the inference of protein complex remodeling from whole-proteome measurements. Nature Methods, 20, 1523–1529. https://doi.org/10.1038/s41592-023-02011-w
