Publication: Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition
Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition
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Masek, M., Etard, C., Hofmann, C., Hülsmeier, A. J., Zang, J., Takamiya, M., Gesemann, M., Neuhauss, S. C. F., Hornemann, T., Strähle, U., & Bachmann-Gagescu, R. (2022). Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition. Nature Communications, 13, 1282. https://doi.org/10.1038/s41467-022-28982-6
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Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders such as Bardet-Biedl syndrome (BBS). Retinal degeneration is common in ciliopathies, since the outer segments (OSs) of photoreceptors are highly specialized primary cilia. BBS1, encoded by the most commonly mutated BBS-associated gene, is part of the BBSome protein complex. Using a bbs1 zebrafish mutant, we show that retinal development and photoreceptor differentiation are unaffected by Bbs1-loss, supported by an initially unaffected transcriptom
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Masek, M., Etard, C., Hofmann, C., Hülsmeier, A. J., Zang, J., Takamiya, M., Gesemann, M., Neuhauss, S. C. F., Hornemann, T., Strähle, U., & Bachmann-Gagescu, R. (2022). Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition. Nature Communications, 13, 1282. https://doi.org/10.1038/s41467-022-28982-6
