Publication: Propofol (Diprivan®) and Intralipid® Exacerbate Insulin Resistance in Type-2 Diabetic Hearts by Impairing GLUT4 Trafficking
Propofol (Diprivan®) and Intralipid® Exacerbate Insulin Resistance in Type-2 Diabetic Hearts by Impairing GLUT4 Trafficking
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Lou, P.-H., Lucchinetti, E., Zhang, L., Affolter, A., Gandhi, M., Zhakupova, A., Hersberger, M., Hornemann, T., Clanachan, A. S., & Zaugg, M. (2015). Propofol (Diprivan®) and Intralipid® Exacerbate Insulin Resistance in Type-2 Diabetic Hearts by Impairing GLUT4 Trafficking. Anesthesia and Analgesia, 120, 329–340. https://doi.org/10.1213/ANE.0000000000000558
Abstract
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BACKGROUND The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown. METHODS Hearts of healthy and type-2 diabetic rats (generated by fructose feeding) were aerobically perfused for 60 minutes with 10 μM propofol in the formulation of Diprivan or an equivalent concentration of its solvent Intralipid (25 μM) ± insulin (100 mU•L). Glucose uptake, glycolysis, and glyc
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Creators (Authors)
- Lou, Phing-How
- Lucchinetti, Eliana
- Zhang, Liyan
- Affolter, Andreas
- Gandhi, Manoj
- Zhakupova, Assem
- Hornemann, Thorsten
- Clanachan, Alexander S
- Zaugg, Michael
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Citations
Lou, P.-H., Lucchinetti, E., Zhang, L., Affolter, A., Gandhi, M., Zhakupova, A., Hersberger, M., Hornemann, T., Clanachan, A. S., & Zaugg, M. (2015). Propofol (Diprivan®) and Intralipid® Exacerbate Insulin Resistance in Type-2 Diabetic Hearts by Impairing GLUT4 Trafficking. Anesthesia and Analgesia, 120, 329–340. https://doi.org/10.1213/ANE.0000000000000558
