Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells

Borrelli, Costanza; Valenta, Tomas; Handler, Kristina; Vélez, Karelia; Gurtner, Alessandra; Moro, Giulia; Lafzi, Atefeh; De Vargas Roditi, Laura; Hausmann, George; Arnold, Isabelle C; Moor, Andreas E; Basler, Konrad

doi:10.5167/uzh-203249

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Borrelli, C., Valenta, T., Handler, K., Vélez, K., Gurtner, A., Moro, G., Lafzi, A., De Vargas Roditi, L., Hausmann, G., Arnold, I. C., Moor, A. E., & Basler, K. (2021). Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells. Nature Communications, 12, 1368. https://doi.org/10.1038/s41467-021-21591-9

Abstract

The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of crypt-resident intestinal epithelial stem cells (IESCs). Wnt/β-catenin signaling is required for IESC maintenance, however, it remains unclear how this pathway selectively governs the identity and proliferative decisions of IESCs. Here, we took advantage of knock-in mice harboring transgenic β-catenin alleles with mutations that specifically impair the recruitment of N- or C-terminal transcriptional co-factors. We show that C-terminally-recruited