Interferon-Mediated Regulation of RNA Virus Infection

Abstract

Influenza A viruses (IAVs) and coronaviruses (CoVs) are respiratory pathogens that cause seasonal infections in humans and occasional pandemics, as last seen by the 2009 H1N1 influenza virus (Swine flu) pandemic and the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Both viruses heavily rely on the host cell machinery for replication, highlighting the tight interplay between host and pathogens. While viruses exploit host functions for their own benefit, the host cell in turn triggers effective antiviral Show more