Acquired HIV drug resistance mutations on first-line antiretroviral therapy in Southern Africa: Systematic review and Bayesian evidence synthesis

Hauser, Anthony; Goldstein, Fardo; Reichmuth, Martina L; Kouyos, Roger D; Wandeler, Gilles; Egger, Matthias; Riou, Julien

doi:10.1016/j.jclinepi.2022.02.005

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Hauser, A., Goldstein, F., Reichmuth, M. L., Kouyos, R. D., Wandeler, G., Egger, M., & Riou, J. (2022). Acquired HIV drug resistance mutations on first-line antiretroviral therapy in Southern Africa: Systematic review and Bayesian evidence synthesis. Journal of Clinical Epidemiology, 148, 135–145. https://doi.org/10.1016/j.jclinepi.2022.02.005

Abstract

OBJECTIVE

To estimate the prevalence of NRTI and NNRTI drug resistance mutations in patients failing NNRTI-based ART in Southern Africa.

STUDY DESIGN

We conducted a systematic review to identify studies reporting drug resistance mutations among adult people living with HIV (PLWH) who experienced virological failure on first-line NNRTI-based ART in Southern Africa. We used a Bayesian hierarchical meta-regression model to synthesize the evidence on the frequency of eight NRTI- and seven NNRTI-DRMs across different ART regimens, accou