Publication: Resting natural killer cell homeostasis relies on tryptophan/NAD$^{+}$ metabolism and HIF-1α
Resting natural killer cell homeostasis relies on tryptophan/NAD$^{+}$ metabolism and HIF-1α
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Pelletier, A., Nelius, E., Fan, Z., Khatchatourova, E., Alvarado-Diaz, A., He, J., Krzywinska, E., Sobecki, M., Nagarajan, S., Kerdiles, Y., Fandrey, J., Gotthardt, D., Sexl, V., de Bock, K., & Stockmann, C. (2023). Resting natural killer cell homeostasis relies on tryptophan/NAD$^{+}$ metabolism and HIF-1α. EMBO Reports, 24(6), e56156. https://doi.org/10.15252/embr.202256156
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Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewiring remains controversial. Activated NK cells are predominantly glycolytic, but the metabolic programs that ensure the maintenance of resting NK cells are enigmatic. By combining in situ metabolomic and transcriptomic analyses in resting murin
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Pelletier, A., Nelius, E., Fan, Z., Khatchatourova, E., Alvarado-Diaz, A., He, J., Krzywinska, E., Sobecki, M., Nagarajan, S., Kerdiles, Y., Fandrey, J., Gotthardt, D., Sexl, V., de Bock, K., & Stockmann, C. (2023). Resting natural killer cell homeostasis relies on tryptophan/NAD$^{+}$ metabolism and HIF-1α. EMBO Reports, 24(6), e56156. https://doi.org/10.15252/embr.202256156
