Publication: Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo
Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo
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Peri, F., & Nüsslein-Volhard, C. (2008). Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo. Cell, 133(5), 916–927. https://doi.org/10.1016/j.cell.2008.04.037
Abstract
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Abstract
A significant proportion of neurons in the brain undergo programmed cell death. In order to prevent the diffusion of damaging degradation products, dying neurons are quickly digested by microglia. Despite the importance of microglia in several neuronal pathologies, the mechanism underlying their degradation of neurons remains elusive. Here, we exploit a microglial population in the zebrafish to study this process in intact living brains. In vivo imaging reveals that digestion of neurons occurs in compartments arising from the progress
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- Peri, Francesca
- Nüsslein-Volhard, Christiane
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Citations
Peri, F., & Nüsslein-Volhard, C. (2008). Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo. Cell, 133(5), 916–927. https://doi.org/10.1016/j.cell.2008.04.037
