Publication: Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study
Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study
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Dieckmann, K.-P., Radtke, A., Geczi, L., et al, Hermanns, T., & Fankhauser, C. D. (2019). Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study. Journal of Clinical Oncology, 37, 1412–1423. https://doi.org/10.1200/JCO.18.01480
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PURPOSE Previous studies suggested that serum levels of microRNA (miR)-371a-3p (so-called M371 test) have a much higher sensitivity and specificity than the classic markers of testicular germ cell tumors (GCTs) and are applicable toward both seminoma and nonseminoma. We sought to confirm the usefulness of this test as a novel biomarker for GCT. PATIENTS AND METHODS In a prospective, multicentric study, serum samples of 616 patients with testicular GCTs and 258 male controls were examined for serum levels of miRNA-371a-3p (miR levels
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- Dieckmann, Klaus-Peter
- Radtke, Arlo
- Geczi, Lajos
- Hermanns, Thomas
- Fankhauser, Christian Daniel
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Dieckmann, K.-P., Radtke, A., Geczi, L., et al, Hermanns, T., & Fankhauser, C. D. (2019). Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study. Journal of Clinical Oncology, 37, 1412–1423. https://doi.org/10.1200/JCO.18.01480
