Immunosuppression and lung cancer of donor origin after bilateral lung transplantation

von Boehmer, Lotta; Draenert, Alice; Jungraithmayr, Wolfgang; Inci, Ilhan; Niklaus, Schäfer; Boehler, Annette; Hofer, Markus; Stahel, Rolf; Soltermann, Alex; van den Broek, Maries; Weder, Walter; Knuth, Alexander

doi:10.1016/j.lungcan.2011.10.001

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von Boehmer, L., Draenert, A., Jungraithmayr, W., Inci, I., Niklaus, S., Boehler, A., Hofer, M., Stahel, R., Soltermann, A., van den Broek, M., Weder, W., & Knuth, A. (2012). Immunosuppression and lung cancer of donor origin after bilateral lung transplantation. Lung Cancer, 76(1), 118–122. https://doi.org/10.1016/j.lungcan.2011.10.001

Abstract

Analysis of databases from transplant recipients revealed a 3-5 fold higher risk to develop de novo malignancies under continued immunosuppression. The underlying mechanisms are poorly understood. Here we describe a patient who received a bilateral lung transplantation for end-stage 'Usual Interstitial Pneumonia' (UIP) resulting in idiopathic lung fibrosis. The recipient presented with a non-small cell lung carcinoma (NSCLC) in the donor lung 7 months later. Molecular and immunological typing of the tumor revealed a cancer of donor or