Publication: Atherosclerosis regression and TP receptor inhibition: effect of S18886 on plaque size and composition—a magnetic resonance imaging study
Atherosclerosis regression and TP receptor inhibition: effect of S18886 on plaque size and composition—a magnetic resonance imaging study
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Viles-Gonzalez, J. F., Fuster, V., Corti, R., Valdiviezo, C., Hutter, R., Corda, S., Anand, S. X., & Badimon, J. J. (2005). Atherosclerosis regression and TP receptor inhibition: effect of S18886 on plaque size and composition—a magnetic resonance imaging study. European Heart Journal, 26(15), 1557–1561. https://doi.org/10.1093/eurheartj/ehi175
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Aims Endothelial dysfunction, platelet hyperactivity, and inflammation play a crucial role in atherogenesis. A growing body of evidence suggests that inhibition of the thromboxane A2 (TxA2 or TP) receptor may improve endothelial function and reduce the inflammatory component of atherosclerosis in addition to its demonstrated antiplatelet activity. Consequently, we sought to assess the effect of a novel TP receptor antagonist S18886, on atherosclerotic lesion progression and composition by serial non-invasive magnetic resonance imaging
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- Viles-Gonzalez, Juan F
- Fuster, Valentin
- Corti, Roberto
- Valdiviezo, Carolina
- Hutter, Randolph
- Corda, Stefano
- Anand, Sunil X
- Badimon, Juan J
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Viles-Gonzalez, J. F., Fuster, V., Corti, R., Valdiviezo, C., Hutter, R., Corda, S., Anand, S. X., & Badimon, J. J. (2005). Atherosclerosis regression and TP receptor inhibition: effect of S18886 on plaque size and composition—a magnetic resonance imaging study. European Heart Journal, 26(15), 1557–1561. https://doi.org/10.1093/eurheartj/ehi175
