Publication: Genome editing of human primary keratinocytes by CRISPR/Cas9 reveals an essential role of the NLRP1 inflammasome in UVB sensing
Genome editing of human primary keratinocytes by CRISPR/Cas9 reveals an essential role of the NLRP1 inflammasome in UVB sensing
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Fenini, G., Grossi, S., Contassot, E., Biedermann, T., Reichmann, E., French, L. E., & Beer, H.-D. (2018). Genome editing of human primary keratinocytes by CRISPR/Cas9 reveals an essential role of the NLRP1 inflammasome in UVB sensing. Journal of Investigative Dermatology, 138(12), 2644–2652. https://doi.org/10.1016/j.jid.2018.07.016
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By forming a protective barrier, epidermal keratinocytes represent the first line of defense against environmental insults. UVB radiation of the sun is a major challenge for the skin and can induce inflammation, aging and eventually skin cancer. UVB induces an immune response in human keratinocytes resulting in activation and secretion of the pro-inflammatory cytokines proIL-1β and -18. This is mediated by assembly of protein complexes, termed inflammasomes. However, the mechanisms underlying sensing of UVB by keratinocytes, and parti
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- Fenini, Gabriele
- Grossi, Serena
- Contassot, Emmanuel
- Biedermann, Thomas
- Reichmann, Ernst
- French, Lars E
- Beer, Hans-Dietmar
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Fenini, G., Grossi, S., Contassot, E., Biedermann, T., Reichmann, E., French, L. E., & Beer, H.-D. (2018). Genome editing of human primary keratinocytes by CRISPR/Cas9 reveals an essential role of the NLRP1 inflammasome in UVB sensing. Journal of Investigative Dermatology, 138(12), 2644–2652. https://doi.org/10.1016/j.jid.2018.07.016
