Publication: Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity
Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity
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Pfefferlé, M., Dubach, I. L., Buzzi, R. M., Dürst, E., Schulthess-Lutz, N., Baselgia, L., Hansen, K., Imhof, L., Koernig, S., Le Roy, D., Roger, T., Humar, R., Schaer, D. J., & Vallelian, F. (2023). Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity. Journal for ImmunoTherapy of Cancer, 11, e005718. https://doi.org/10.1136/jitc-2022-005718
Abstract
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Abstract
BackgroundAgonistic anti-CD40 monoclonal antibodies (mAbs) have emerged as promising immunotherapeutic compounds with impressive antitumor effects in mouse models. However, preclinical and clinical studies faced dose-limiting toxicities mediated by necroinflammatory liver disease. An effective prophylactic treatment for liver immune-related adverse events that does not suppress specific antitumor immunity remains to be found.MethodsWe used different mouse models and time-resolved single-cell RNA-sequencing to characterize the pathogen
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- Pfefferlé, Marc
- Dubach, Irina L
- Dürst, Elena
- Schulthess-Lutz, Nadja
- Baselgia, Livio
- Hansen, Kerstin
- Imhof, Larissa
- Koernig, Sandra
- Le Roy, Didier
- Roger, Thierry
- Humar, Rok
- Schaer, Dominik J
- Vallelian, Florence
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Pfefferlé, M., Dubach, I. L., Buzzi, R. M., Dürst, E., Schulthess-Lutz, N., Baselgia, L., Hansen, K., Imhof, L., Koernig, S., Le Roy, D., Roger, T., Humar, R., Schaer, D. J., & Vallelian, F. (2023). Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity. Journal for ImmunoTherapy of Cancer, 11, e005718. https://doi.org/10.1136/jitc-2022-005718
