Publication: Clinical Trial: Safety and Efficacy of a Novel Oesophageal Delivery System for Topical Corticosteroids Versus Placebo in the Treatment of Eosinophilic Oesophagitis
Clinical Trial: Safety and Efficacy of a Novel Oesophageal Delivery System for Topical Corticosteroids Versus Placebo in the Treatment of Eosinophilic Oesophagitis
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Lucendo, A. J., Nantes-Castillejo, Ó., Straumann, A., Biedermann, L., Bredenoord, A. J., Guagnozzi, D., Blas-Jhon, L., Wiechowska-Kozlowska, A., Weidlich, S., von Arnim, U., Santander-Vaquero, C., Perelló, A., Pérez-Martínez, I., Barrio, J., Vieth, M., Gouya, G., & Dellon, E. S. (2025). Clinical Trial: Safety and Efficacy of a Novel Oesophageal Delivery System for Topical Corticosteroids Versus Placebo in the Treatment of Eosinophilic Oesophagitis. Alimentary Pharmacology & Therapeutics, 61(3), 444–455. https://doi.org/10.1111/apt.18443
Abstract
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Abstract
BACKGROUND: EsoCap is a thin mucoadhesive film designed to target the oesophageal mucosa. The device loaded with mometasone furoate (ESO-101) is under investigation for the treatment of eosinophilic oesophagitis (EoE).
AIMS: To evaluate the efficacy, safety and tolerability of ESO-101 in patients with active EoE.
METHODS: We conducted a randomised, placebo-controlled, phase 2, proof-of-concept trial at 14 European sites in adults with EoE. Participants received placebo, uncoated EsoCap (n = 15), or EsoCap loaded with 800 μg of momet
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Creators (Authors)
- Lucendo, Alfredo J
- Nantes-Castillejo, Óscar
- Straumann, Alex
- Biedermann, Luc
- Bredenoord, Albert J
- Guagnozzi, Danila
- Blas-Jhon, Leonardo
- Wiechowska-Kozlowska, Anna
- Weidlich, Simon
- von Arnim, Ulrike
- Santander-Vaquero, Cecilio
- Perelló, Antonia
- Pérez-Martínez, Isabel
- Barrio, Jesús
- Vieth, Michael
- Gouya, Ghazaleh
- Dellon, Evan S
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Lucendo, A. J., Nantes-Castillejo, Ó., Straumann, A., Biedermann, L., Bredenoord, A. J., Guagnozzi, D., Blas-Jhon, L., Wiechowska-Kozlowska, A., Weidlich, S., von Arnim, U., Santander-Vaquero, C., Perelló, A., Pérez-Martínez, I., Barrio, J., Vieth, M., Gouya, G., & Dellon, E. S. (2025). Clinical Trial: Safety and Efficacy of a Novel Oesophageal Delivery System for Topical Corticosteroids Versus Placebo in the Treatment of Eosinophilic Oesophagitis. Alimentary Pharmacology & Therapeutics, 61(3), 444–455. https://doi.org/10.1111/apt.18443
