Publication: Functional architecture of the nuclear pore complex
Functional architecture of the nuclear pore complex
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Grossman, E., Medalia, O., & Zwerger, M. (2012). Functional architecture of the nuclear pore complex. Annual Review of Biophysics, 41, 557–584. https://doi.org/10.1146/annurev-biophys-050511-102328
Abstract
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The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous translocation channels that allow the free diffusion of small molecules and ions, as well as receptor-mediated transport of large macromolecules. The NPC regulates nucleocytoplasmic transport of macromolecules, utilizing soluble receptors that identify and present cargo to the NPC, in a highly selective manner to maintain cellular functions. The NPC is composed of multiple copies of
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- Grossman, Einat
- Medalia, Ohad
- Zwerger, Monika
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Citations
Grossman, E., Medalia, O., & Zwerger, M. (2012). Functional architecture of the nuclear pore complex. Annual Review of Biophysics, 41, 557–584. https://doi.org/10.1146/annurev-biophys-050511-102328
