Publication: Organometallic Derivatives of Decoquinate Targeted toward Toxoplasma gondii
Organometallic Derivatives of Decoquinate Targeted toward Toxoplasma gondii
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Betts, H. D., Ong, Y. C., Anghel, N., Keller, S., Karges, J., Voutsara, N., Müller, J., Manoury, E., Blacque, O., Cariou, K., Hemphill, A., & Gasser, G. (2022). Organometallic Derivatives of Decoquinate Targeted toward Toxoplasma gondii. Organometallics, 41(15), 2035–2041. https://doi.org/10.1021/acs.organomet.2c00204
Abstract
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Toxoplasmosis is an infection contracted by exposure to Toxoplasma gondii and can have deleterious health effects on pregnant women and their children. Current treatments for the infection are complex and have considerable undesired side effects, raising the need for new treatments. Herein, we report the synthesis, characterization, and biological testing of some organometallic derivatives of the commercially available, broad-spectrum antiparasitic, decoquinate (DCQ). The cyclic secondary amine of decoquinate was functionalized with a
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- Betts, Harley D
- Ong, Yih Ching
- Anghel, Nicoleta
- Keller, Sarah
- Karges, Johannes
- Voutsara, Niovi
- Müller, Joachim
- Manoury, Eric
- Cariou, Kevin
- Hemphill, Andrew
- Gasser, Gilles
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Betts, H. D., Ong, Y. C., Anghel, N., Keller, S., Karges, J., Voutsara, N., Müller, J., Manoury, E., Blacque, O., Cariou, K., Hemphill, A., & Gasser, G. (2022). Organometallic Derivatives of Decoquinate Targeted toward Toxoplasma gondii. Organometallics, 41(15), 2035–2041. https://doi.org/10.1021/acs.organomet.2c00204
