Diet-derived protein and amino acids attenuate the responsiveness of the area postrema to the anorectic hormone amylin in male rats

Abstract

The pancreatic β-cell hormone amylin decreases food intake via activation of brainstem neurons in the area postrema (AP). Diet-derived protein is thought to attenuate amylin responsiveness. Here we investigated the influence of isocaloric diets with differing protein contents on the amylin–dependent AP activation (c-Fos expression) and food intake suppression. Further, we investigated whether circulating amino acids affect these amylin actions. Finally, we characterized the possible interaction between amylin and glucagon, which is se Show more