Autologous transplantation of adipose-derived stem cells improves functional recovery of skeletal muscle without direct participation in new myofiber formation

Gorecka, Agata; Salemi, Souzan; Haralampieva, Deana; Moalli, Federica; Stroka, Deborah; Candinas, Daniel; Eberli, Daniel; Brugger, Lukas

doi:10.1186/s13287-018-0922-1

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Gorecka, A., Salemi, S., Haralampieva, D., Moalli, F., Stroka, D., Candinas, D., Eberli, D., & Brugger, L. (2018). Autologous transplantation of adipose-derived stem cells improves functional recovery of skeletal muscle without direct participation in new myofiber formation. Stem Cell Research & Therapy, 9(1), 195. https://doi.org/10.1186/s13287-018-0922-1

Abstract

BACKGROUND: Skeletal muscle has a remarkable regenerative capacity. However, extensive damage that exceeds the self-regenerative ability of the muscle can lead to irreversible fibrosis, scarring, and significant loss of function. Adipose-derived stem cells (ADSC) are a highly abundant source of progenitor cells that have been previously reported to support the regeneration of various muscle tissues, including striated muscles. The aim of this study was to evaluate the effect of ADSC transplantation on functional skeletal muscle regene