Publication: Liver X receptor inhibition potentiates mitotane-induced adrenotoxicity in ACC
Liver X receptor inhibition potentiates mitotane-induced adrenotoxicity in ACC
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Warde, K. M., Schoenmakers, E., Ribes Martinez, E., Lim, Y. J., Leonard, M., Lawless, S. J., O’Shea, P., Chatterjee, K. V., Gurnell, M., Hantel, C., & Dennedy, M. C. (2020). Liver X receptor inhibition potentiates mitotane-induced adrenotoxicity in ACC. Endocrine-Related Cancer, 27(6), 361–373. https://doi.org/10.1530/ERC-20-0031
Abstract
Abstract
Abstract
Adrenocortical carcinoma (ACC) is a rare aggressive malignancy with a poor outcome largely due to limited treatment options. Here, we propose a novel therapeutic approach through modulating intracellular free cholesterol via the liver X receptor alpha (LXRα) in combination with current first-line pharmacotherapy, mitotane. H295R and MUC-1 ACC cell lines were pretreated with LXRα inhibitors in combination with mitotane. In H295R, mitotane (20, 40 and 50 µM) induced dose-dependent cell death; however, in MUC-1, this only occurred at a s
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- Warde, Kate M
- Schoenmakers, Erik
- Ribes Martinez, Eduardo
- Lim, Yi Jan
- Leonard, Maeve
- Lawless, Sarah J
- Chatterjee, Krishna V
- Gurnell, Mark
- Hantel, Constanze
- Dennedy, Michael Conall
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Warde, K. M., Schoenmakers, E., Ribes Martinez, E., Lim, Y. J., Leonard, M., Lawless, S. J., O’Shea, P., Chatterjee, K. V., Gurnell, M., Hantel, C., & Dennedy, M. C. (2020). Liver X receptor inhibition potentiates mitotane-induced adrenotoxicity in ACC. Endocrine-Related Cancer, 27(6), 361–373. https://doi.org/10.1530/ERC-20-0031
