Publication: Subacute endotoxemia induces adipose inflammation and changes in lipid and lipoprotein metabolism in cats
Subacute endotoxemia induces adipose inflammation and changes in lipid and lipoprotein metabolism in cats
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Osto, M., Zini, E., Franchini, M., Wolfrum, C., Guscetti, F., Hafner, M., Ackermann, M., Reusch, C. E., & Lutz, T. A. (2011). Subacute endotoxemia induces adipose inflammation and changes in lipid and lipoprotein metabolism in cats. Endocrinology, 152(3), 804–815. https://doi.org/10.1210/en.2010-0999
Abstract
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Abstract
Acute inflammation in humans is associated with transient insulin resistance (IR) and dyslipidemia. Chronic low-grade inflammation is a pathogenic component of IR and adipose tissue dysfunction in obesity-induced type 2 diabetes. Because feline diabetes closely resembles human type 2 diabetes, we studied whether lipopolysaccharide (LPS)-induced subacute inflammation, in the absence of obesity, is the potential primary cause of IR and metabolic disorders. Cats received increasing iv doses (10-1000 ng/kg(-1) · h(-1)) of LPS (n = 5) or s
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Creators (Authors)
- Osto, Melania
- Zini, Eric
- Franchini, M
- Wolfrum, C
- Guscetti, Franco
- Hafner, M
- Ackermann, Mathias
- Reusch, Claudia E
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Citations
Osto, M., Zini, E., Franchini, M., Wolfrum, C., Guscetti, F., Hafner, M., Ackermann, M., Reusch, C. E., & Lutz, T. A. (2011). Subacute endotoxemia induces adipose inflammation and changes in lipid and lipoprotein metabolism in cats. Endocrinology, 152(3), 804–815. https://doi.org/10.1210/en.2010-0999
