Publication: The p66Shc knocked out mice are short lived under natural condition
The p66Shc knocked out mice are short lived under natural condition
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Giorgio, M., Berry, A., Berniakovich, I., Poletaeva, I., Trinei, M., Stendardo, M., Hagopian, K., Ramsey, J. J., Cortopassi, G., Migliaccio, E., Nötzli, S., Amrein, I., Lipp, H. P., Cirulli, F., & Pelicci, P. G. (2012). The p66Shc knocked out mice are short lived under natural condition. Aging Cell, 11(1), 162–168. https://doi.org/10.1111/j.1474-9726.2011.00770.x
Abstract
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Abstract
Deletion of the p66(Shc) gene results in lean and healthy mice, retards aging, and protects from aging-associated diseases, raising the question of why p66(Shc) has been selected, and what is its physiological role. We have investigated survival and reproduction of p66(Shc)-/- mice in a population living in a large outdoor enclosure for a year, subjected to food competition and exposed to winter temperatures. Under these conditions, deletion of p66(Shc) was strongly counterselected. Laboratory studies revealed that p66(Shc)-/- mice ha
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Creators (Authors)
- Giorgio, Marco
- Berry, Alessandra
- Berniakovich, Ina
- Poletaeva, Inga
- Trinei, Mirella
- Stendardo, Massimo
- Hagopian, Kevork
- Ramsey, Jon J
- Cortopassi, Gino
- Migliaccio, Enrica
- Nötzli, Sarah
- Amrein, Irmgard
- Lipp, Hans P
- Cirulli, Francesca
- Pelicci, Pier G
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Giorgio, M., Berry, A., Berniakovich, I., Poletaeva, I., Trinei, M., Stendardo, M., Hagopian, K., Ramsey, J. J., Cortopassi, G., Migliaccio, E., Nötzli, S., Amrein, I., Lipp, H. P., Cirulli, F., & Pelicci, P. G. (2012). The p66Shc knocked out mice are short lived under natural condition. Aging Cell, 11(1), 162–168. https://doi.org/10.1111/j.1474-9726.2011.00770.x
