Publication: Expression of single-chain antibody against RgpA protease of Porphyromonas gingivalis in Lactobacillus.
Expression of single-chain antibody against RgpA protease of Porphyromonas gingivalis in Lactobacillus.
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Marcotte, H., Kõll-Klais, P., Hultberg, A., Zhao, Y., Gmür, R., Mändar, R., Mikelsaar, M., & Hammarström, L. (2006). Expression of single-chain antibody against RgpA protease of Porphyromonas gingivalis in Lactobacillus. Journal of Applied Microbiology, 100(2), 256–263. https://doi.org/10.1111/j.1365-2672.2005.02786.x
Abstract
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AIMS: The monoclonal antibody 61BG1.3, recognizing the RgpA protease, has been reported to confer protection against recolonization by the periodontal pathogen Porphyromonas gingivalis in humans. The aim of this study was to express a functional scFv derived from the monoclonal antibody 61BG1.3 on the surface of Lactobacillus paracasei for potential use in the prevention or treatment of periodontal diseases. METHODS AND RESULTS: The scFv was fused to an E-tag and cloned in the Escherischia coli/Lactobacillus shuttle vector pLP501, whi
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- Marcotte, H
- Kõll-Klais, P
- Hultberg, A
- Zhao, Y
- Gmür, R
- Mändar, R
- Mikelsaar, M
- Hammarström, L
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Marcotte, H., Kõll-Klais, P., Hultberg, A., Zhao, Y., Gmür, R., Mändar, R., Mikelsaar, M., & Hammarström, L. (2006). Expression of single-chain antibody against RgpA protease of Porphyromonas gingivalis in Lactobacillus. Journal of Applied Microbiology, 100(2), 256–263. https://doi.org/10.1111/j.1365-2672.2005.02786.x