Publication: Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures
Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures
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Chatterjee, S., Zagelbaum, J., Savitsky, P., Sturzenegger, A., Huttner, D., Janscak, P., Hickson, I. D., Gileadi, O., & Rothenberg, E. (2014). Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures. Nature Communications, 5, 5556. https://doi.org/10.1038/ncomms6556
Abstract
Abstract
Abstract
Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BLM that is associated with growth retardation and predisposition to cancer. BLM helicase has a high specificity for non-canonical G-quadruplex (G4) DNA structures, which are formed by G-rich DNA strands and play an important role in the maintenance of genomic integrity. Here we used single-molecule FRET to define the mechanism of interaction of BLM helicase with intra-stranded G4 structures. We show that the activity of BLM is substrate
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Creators (Authors)
- Chatterjee, Sujoy
- Zagelbaum, Jennifer
- Savitsky, Pavel
- Sturzenegger, Andreas
- Huttner, Diana
- Janscak, Pavel
- Hickson, Ian D
- Gileadi, Opher
- Rothenberg, Eli
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Citations
Chatterjee, S., Zagelbaum, J., Savitsky, P., Sturzenegger, A., Huttner, D., Janscak, P., Hickson, I. D., Gileadi, O., & Rothenberg, E. (2014). Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures. Nature Communications, 5, 5556. https://doi.org/10.1038/ncomms6556
