Publication: The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
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Meerang, M., Ritz, D., Paliwal, S., Garajova, Z., Bosshard, M., Mailand, N., Janscak, P., Hübscher, U., Meyer, H., & Ramadan, K. (2011). The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nature Cell Biology, 13, 1376–1382. https://doi.org/10.1038/ncb2367
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Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cascade, but how ubiquitylation coordinates the dynamic assembly of these complexes is poorly understood. Here, we show that the human ubiquitin-selective protein segregase p97 (also known as VCP; valosin-containing protein) cooperates with th
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- Meerang, M
- Ritz, D
- Paliwal, S
- Garajova, Z
- Bosshard, M
- Mailand, N
- Janscak, Pavel
- Hübscher, U
- Meyer, H
- Ramadan, K
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Meerang, M., Ritz, D., Paliwal, S., Garajova, Z., Bosshard, M., Mailand, N., Janscak, P., Hübscher, U., Meyer, H., & Ramadan, K. (2011). The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nature Cell Biology, 13, 1376–1382. https://doi.org/10.1038/ncb2367
