Publication: Clinical consequences of developmental programming of low nephron number
Clinical consequences of developmental programming of low nephron number
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Luyckx, V. A., & Brenner, B. M. (2020). Clinical consequences of developmental programming of low nephron number. The Anatomical Record, 303(10), 2613–2631. https://doi.org/10.1002/ar.24270
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Nephron number in humans varies up to 13-fold, likely reflecting the impact of multiple factors on kidney development, including inherited body size and ethnicity, as well as maternal health and nutrition, fetal exposure to gestational diabetes or preeclampsia and other environmental factors, which may potentially be modifiable. Such conditions predispose to low or high offspring birth weight, growth restriction or preterm birth, which have all been associated with increased risks of higher blood pressures and/or kidney dysfunction in
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- Luyckx, Valerie A
- Brenner, Barry M
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Luyckx, V. A., & Brenner, B. M. (2020). Clinical consequences of developmental programming of low nephron number. The Anatomical Record, 303(10), 2613–2631. https://doi.org/10.1002/ar.24270