Publication: Preclinical Evidence of Progesterone as a New Pharmacological Strategy in Human Adrenocortical Carcinoma Cell Lines
Preclinical Evidence of Progesterone as a New Pharmacological Strategy in Human Adrenocortical Carcinoma Cell Lines
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Tamburello, M., Abate, A., Rossini, E., Basnet, R. M., Zizioli, D., Cosentini, D., Hantel, C., Laganà, M., Tiberio, G. A. M., Grisanti, S., Memo, M., Berruti, A., & Sigala, S. (2023). Preclinical Evidence of Progesterone as a New Pharmacological Strategy in Human Adrenocortical Carcinoma Cell Lines. International Journal of Molecular Sciences, 24(7), 6829. https://doi.org/10.3390/ijms24076829
Abstract
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Abstract
BACKGROUND
Adrenocortical cancer (ACC) is a rare malignancy with a dismal prognosis. The treatment includes mitotane and EDP chemotherapy (etoposide, doxorubicin, and cisplatin). However, new therapeutic approaches for advanced ACC are needed, particularly targeting the metastatic process. Here, we deepen the role of progesterone as a new potential drug for ACC, in line with its antitumoral effect in other cancers.
METHODS
NCI-H295R, MUC-1, and TVBF-7 cell lines were used and xenografted in zebrafish embryos. Migration and invasion
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Creators (Authors)
- Tamburello, Mariangela
- Abate, Andrea
- Rossini, Elisa
- Basnet, Ram Manohar
- Zizioli, Daniela
- Cosentini, Deborah
- Hantel, Constanze
- Laganà, Marta
- Tiberio, Guido Alberto Massimo
- Grisanti, Salvatore
- Memo, Maurizio
- Berruti, Alfredo
- Sigala, Sandra
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Tamburello, M., Abate, A., Rossini, E., Basnet, R. M., Zizioli, D., Cosentini, D., Hantel, C., Laganà, M., Tiberio, G. A. M., Grisanti, S., Memo, M., Berruti, A., & Sigala, S. (2023). Preclinical Evidence of Progesterone as a New Pharmacological Strategy in Human Adrenocortical Carcinoma Cell Lines. International Journal of Molecular Sciences, 24(7), 6829. https://doi.org/10.3390/ijms24076829
