Publication: Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification
Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification
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Sauser, L., Kalvoda, T., Kavas, A., Rulíšek, L., & Shoshan, M. S. (2022). Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification. ChemMedChem, 17(15), e202200152. https://doi.org/10.1002/cmdc.202200152
Abstract
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Abstract
A rationally-designed scaffold of cyclic octapeptides composed of two units of the natural tripeptide glutathione (GSH) was optimized to strongly and selectively capture toxic lead ions (Pb(II)). Using state-of-the-art computational tools, a list of eleven plausible peptides was shortened to five analogs based on their calculated affinity to Pb(II) ions. We then synthesized and investigated them for their abilities to recover Pb-poisoned human cells. A clear pattern was observed from the in vitro detoxification results, indicating the
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- Sauser, Luca
- Kalvoda, Tadeáš
- Kavas, Ayça
- Rulíšek, Lubomír
- Shoshan, Michal S
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Sauser, L., Kalvoda, T., Kavas, A., Rulíšek, L., & Shoshan, M. S. (2022). Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification. ChemMedChem, 17(15), e202200152. https://doi.org/10.1002/cmdc.202200152
