Publication: Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.
Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.
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Bellosta, P., Hulf, T., Balla Diop, S., Usseglio, F., Pradel, J., Aragnol, D., & Gallant, P. (2005). Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development. Proceedings of the National Academy of Sciences of the United States of America, 102(33), 11799–11804. https://doi.org/10.1073/pnas.0408945102
Abstract
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Abstract
The transcription factor dMyc is the sole Drosophila ortholog of the vertebrate c-myc protooncogenes and a central regulator of growth and cell-cycle progression during normal development. We have investigated the molecular basis of dMyc function by analyzing its interaction with the putative transcriptional cofactors Tip48/Reptin (Rept) and Tip49/Pontin (Pont). We demonstrate that Rept and Pont have conserved their ability to bind to Myc during evolution. All three proteins are required for tissue growth in vivo, because mitotic clon
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Creators (Authors)
- Bellosta, P
- Hulf, T
- Balla Diop, S
- Usseglio, F
- Pradel, J
- Aragnol, D
- Gallant, P
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Citations
Bellosta, P., Hulf, T., Balla Diop, S., Usseglio, F., Pradel, J., Aragnol, D., & Gallant, P. (2005). Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development. Proceedings of the National Academy of Sciences of the United States of America, 102(33), 11799–11804. https://doi.org/10.1073/pnas.0408945102
